bactericidal material based on silver nanoparticles

bactericidal material based on silver nanoparticles

Connection with silver nanoparticles destroys the biofilm. Source: Dmytro Kopitsyn

Russian scientists, together with colleagues from Brazil, have developed a bactericidal material that can be used as part of paints and coatings in infectious and surgical departments. In the future, the technology can also be used in the creation of medical implants. It is based on a clay material with the addition of silver nanoparticles and phosphoromolybdic acid. The latter enhances the release of silver ions that kill pathogenic microorganisms. The results of the research, supported by a grant from the Russian Science Foundation (RSF), were published in the journal JCIS Open.

Scientists from Gubkin University, Institute of Physical Chemistry and Electrochemistry named after O.M. Frumkin of the Russian Academy of Sciences, Karaganda Medical University and the Chemical Institute of San Carlos (Brazil) have created a material that can become an alternative to traditional antibiotics for the destruction of pathogenic bacteria and bacterial biofilms. The development can be used as part of paints or other materials for surface treatment of objects, furniture and tools. In the future, the technology may also find application in medicine, in particular during the creation of implants.

As the authors of the work noted, antibacterial coatings are used in medical facilities, food industries, and also in everyday life. One of the most frequently used antibacterial components is colloidal silver – a solution of metal nanoparticles. Nanoparticles are able to fight not only with bacteria, but also with their biofilms (colonies of microorganisms, the cells of which are attached to each other. — RT). Such biofilms are particularly resistant to antibiotics and antiseptics.

Scientists have developed a material with an antibacterial and anti-biofilm effect. It is a composite of silver nanoparticles and phosphoromolybdic acid on a carrier made of the natural mineral hallusite.

The researchers applied silver to the clay carrier, which provided the material with antibacterial properties. Phosphoromolybdic acid plays the role of an oxidizer in the composite and was added to increase the activity of releasing silver ions.

The authors of the work confirmed the effectiveness of the new material in laboratory conditions. They applied the substance to biofilms of bacteria Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii, which cause pneumonia and urinary tract diseases. Experiments have shown that the composite suppresses the growth of microorganisms twice as effectively as a conventional solution of silver nanoparticles. Moreover, the material reduced the viability of biofilms of pathogenic bacteria by more than four orders of magnitude.

According to the developers, the obtained material should be used in a higher concentration than traditional antibiotics. However, it is well suited for local application as part of paints or other materials for surface treatment of objects, furniture, and tools. This will prevent the spread of bacteria resistant to antimicrobial drugs, which is especially relevant in the conditions of infectious and surgical hospitals.

If phosphoromolybdic acid is replaced with more biocompatible components, such substances can be used in medicine in the future, the researchers noted.

“Surgeries are often complicated by the patient’s chronic diseases or suppuration processes caused by bacterial infections. Many antibiotics have to be added locally, which can cause bacteria to become resistant to them. Now we are working to ensure that our material can be included in the composition of bone cements or used to cover the surface of implants in order to increase their survival and avoid suppuration after surgery,” Dmytro Kopitsyn, head of the project, a leading researcher at Gubkin University, told RT.

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